Frequently Asked Questions

The following are Frequently Asked Questions answered.

Hello, I have wet macular degeneration and want to start taking Macushield. Is it safe to take along with Bilberry extract, grapeseed extract and Omega 3 vitamins? I have been taking I-Caps for one month but have read information that suggests Macushield may be better as it contains MZ.

Macushield is a dietary supplement which contains the three macular carotenoids; lutein, zeaxanthin and meso-zeaxanthin, which are naturally occurring carotenoids found in nature. A recent study conducted by the research group in Waterford has shown that there are no adverse side effects from taking a supplement containing the three macular carotenoids. This study was conducted on patients who were also taking additional food supplements such as the ones you are currently taking. There have also been many other animal and human studies conducted to investigate the safety of consuming carotenoids such as those contained in Macushield. These can be found on the Publications page of this website.

I am a 73 year old female with dry AMD. Can MZ help me at this stage or age?

We would strongly recommend that you take a supplement containing meso-zeaxanthin, especially because of your age and the fact that you have AMD. A supplement containing all three macular carotenoids such as Macushield (available in pharmacies and opticians), is aimed at promoting a healthy macula, the part of the back of the eye affected by AMD. Research has shown that the eye pigments such as MZ may play a role in reducing risk of developing advanced stage AMD. As you have AMD we recommend that you visit your ophthalmologist regularly.

What is astaxanthin and if you are taking Macushield for macular degeneration would you need it, or does the meso-zeaxanthin do the same thing?

Lutein, zeaxanthin and meso-zeaxanthin are carotenoids (naturally occurring plant pigments). These carotenoids are found at the back of the eye; the macula. Research has shown that macular pigment (the yellow pigment at the macula believed to protect against age-related macular degeneration, or AMD) increases upon supplementation with lutein, zeaxanthin and meso-zeaxanthin, and that macular pigment increases are higher when all three are taken together.

Astaxanthin is also a carotenoid like lutein, zeaxanthin and meso-zeaxanthin, but to our knowledge it is not found in the eye. It is typically used as a food colourant given its bright colour.

Please let me know what the benefits are of meso-zeaxanthin versus omega 3.

Omega-3 fatty acid and meso-zeaxanthin are very different compounds with very different functions. Omega-3 is a fatty acid, a naturally occurring fat found in fish and plant oils. Omega-3 is believed to be important as it may help replace the damaged cells at the back of the eye (photoreceptors). Typically these cells at the back of the eye which are required for vision are destroyed when AMD develops. The idea, therefore, is that Omega-3 may help replace the destroyed cells at the back of the eye. However, research has not yet confirmed that this is the case and further study is needed.

Meso-zeaxanthin (MZ), on the other hand, is believed to be important as it has the required properties to protect the cells at the back of the eye before they are damaged. In other words, MZ may prevent the disease and Omega-3 may be important to replenish damaged cells.

My wife was diagnosed with AMD two months ago. We immediately went to the hospital, where the diagnosis was confirmed. My wife immediately started taking Macushield upon recommendation from the ophthalmologist. The photos showed most obviously that the cyst had reduced significantly. My wife will of course continue to take the Macushield and, in fact, her vision is still distorted and with some strange colour effects (particularly yellow). But I wonder if it is possible that the Macushield is significantly responsible for the improvement. Or is it a happy chance - even though the Macushield may have helped.

We are glad to hear your wife's positive results. Over the last number of years we have learned of similar cases to your wife’s situation, and this is consistent with a recent survey performed in the UK and Ireland. Scientists and doctors understandably interpret individual cases with caution. However, case studies do contribute to the scientific evidence base which the medical and scientific organisations learn from. With respect to the reduced cyst identified, this is good news and may or may not be related to the supplement. The important thing to observe is if visual performance is improving or at least staying the same. Clinical trials have shown that supplementation with Macushield does, indeed, improve visual performance in patients with AMD. However, the benefits for the disease itself have not yet been confirmed and require continued study which is currently underway. We would recommend that your wife continues taking Macushield and remains under the observation of her ophthalmologist and other eyecare specialists.

I am about to start taking a vitamin with lutein, zeaxanthin and meso-zeaxanthin (MZ). The formulation has 10mg of lutein, 2mg of zeaxanthin and 10mg of MZ. Since I have AMD, what is the maximum amount of these ingredients I can take to benefit me?

Where can I source and purchase the MZ material?

MZ is only commercially available within a supplement called Macushield (http://www.macushield.co.uk).

It is written on your website that "research has also shown that individuals at risk of developing AMD are lacking in MZ, suggesting that these individuals are unable to form MZ from L at this important retinal location, but do respond positively when MZ is provided in a dietary supplement. The researchers suggested that the deficiency of MZ generation in such individuals may be genetic." This is very interesting: could you send me the reference?

Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory study.
Curr Eye Res. 2010 Apr;35(4):335-51.
Connolly EE, Beatty S, Thurnham DI, Loughman J, Howard AN, Stack J, Nolan JM.
www.ncbi.nlm.nih.gov/pubmed/20373901

A central dip in the macular pigment spatial profile is associated with age and smoking.
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6722-8. Epub 2010 Jun 30.
Kirby ML, Beatty S, Loane E, Akkali MC, Connolly EE, Stack J, Nolan JM.
http://www.ncbi.nlm.nih.gov/pubmed/20592234

Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment.
John M Nolan, Mukunda C Akkali, James Loughman, Alan N Howard, Stephen Beatty
http://www.sciencedirect.com/science/article/pii/S0014483512001492?v=s5

In addition to supplements, what else do you recommend to help prevent AMD?

There are other steps you can take to keep your eyes healthy. Try to consume at least five portions of fruit and vegetables a day, especially brightly coloured ones like spinach, curly kale, peppers, sweetcorn, red grapes and oranges; also egg yolks. Do not smoke, as smoking is an established risk factor for AMD. Try to wear protective sunglasses or lenses when you are in bright light (either sunlight or artificial light). Keep your body mass index (BMI) under control, as well as blood pressure and cholesterol.

AMD is a genetic eye disease, which means that if you have AMD, any siblings or children you have may be at a higher risk of AMD themselves, and should also take the preventative measures listed above.

Visit http://www.sightrisk.com for more information on AMD risk factors.

Do you know any natural source of meso-zeaxanthin?

There has not been much research conducted to date on the source of meso-zeaxanthin (MZ), however, one publication (Maoka et al) has stated that some seafood (e.g. sea bass, trout) contains amounts of MZ, and it is thought that MZ is most concentrated in the skin of the fish. However, although these foods did contain MZ they did so in very small amounts. Research is currently ongoing (at the Waterford Institute of Technology, Waterford, Ireland, and Tufts University, Boston, USA) to test if other foods (e.g. eggs) contain MZ. Therefore, based on the information that is currently available, the only major known source of MZ is the dietary eye-related supplement called MacuShield.

Maoka et al 1985 "The first isolation of enantiomeric and meso-zeaxanthin in nature": http://www.ncbi.nlm.nih.gov/pubmed/3943294

Where can I purchase mesozeaxanthin? Is it sold separately so I can take it with the pills I now take with Lutein and Zeaxanthin? I found a product on line that contains all three ingredients; however the amount of mesozeaxthin is not nearly enough. My doctor told me I need 15mg of lutein, 5 mg zeaxanthin and 10 mg meso-zeaxanthin?

There is a commercially available product called Macushield that contains all three macular carotenoids; lutein, zeaxanthin and meso-zeaxanthin. This product is available in most Uk pharmacies and optician practices. Visit http://www.macushield.co.uk for information. This product contains Lutein, zeaxanthin and meso-zeaxanthin in appropriate amounts.

Does meso-zeaxanthin go by any other name? Is it included in the Bausch and Lomb preservision Areds 2 formula?

Meso-zeaxanthin does not go by any other name. Also, it is not part of the AREDS 2 formula. Therefore, the AREDS 2 results will not be investigating the potential of meso-zeaxanthin for patients with AMD. Many other trials are, however, investigating the potential of this central macular carotenoid.

Can you tell me the difference between Meso-zeaxanthin and Zeaxanthin please? A recent eye-test revealed that I have drusen. My sister has AMD (the wrong sort) and I have been recommended to take MacuShield which uniquely contains both these, but the suspicious side of me wonders whether it's Boots way of making more money when I can buy cheaper supplements that lack MZ but contains just the Z.

Lutein, zeaxanthin and meso-zeaxanthin are very similar molecules (scientifically, they are known as structural isomers). However, they are also different molecules in that they are shaped differently and function differently with respect to their antioxidant capacity and ability to filter light. We know that best results are seen when all three are present in the supplement. This is likely why the eye has evolved to have the three present.

Do Macushield capsules contain Omega 3 ?

No macushield do not contain omega 3. Macushield only contains the macular carotenoids to help protect the central macula.

I have been recommended macushield by my optician but he suggested I check the contents as I also take multibionta probiotic tablets which contain a range of vitamins. Do your tablets contain everyday vitamins as well?

Macushied does not contain any multivitamins. It is a specialised eye supplement containing the macular carotenoids only

Is there any evidence base of a beneficial effect of Meso-Zeaxantin as a prophylaxis against Macular Degeneration?

Only insofar as the following: macular pigment (MP) is lacking decades before onset of age-related macular degeneration (AMD) [Nolan J et al, 2007], and the best means of increasing MP is by means of supplementation with meso-zeaxanthin [Sabour-Pickett S et al, 2014);

I have myopic macular degeneration with CNV in my right eye. Would lutein, zeaxanthin & meso-zeaxanthin supplement have any effect on the condition of my macular degeneration?

It is known that a supplement containing L, Z and MZ represents the best way of preserving vision in age-related macular degeneration (AMD); myopic macular degeneration represents a risk to vision for the same reasons as AMD (I.e. atrophy and choroidal neovascularisation); therefore, there is a biologically plausible rationale whereby Macushield would benefit patients with myopic macular degeneration

Hi ,my mum has md as well as glaucoma ,is it ok to take macushield ?

Yes, one of the benefits of enhancing macular pigment is its ability to reduce the effects of light scatter and glare. We know that patients with Glaucoma suffer greatly with glare and we also know that patients with Glaucoma have lower macular pigment.

I am on a "new" cancer drug called ibrutinib and must not have any inhibitors or inducers of CYP3A4/5 I cannot tell if it would be safe for me to take your product. I have CLL as well as wet and dry macular disease. so would welcome any help with my eyes?

Macushield contains no constituents that are inhibitors or inducers of CYP3A4/5, and it is safe for you to take Macushield, one tablet once daily.

I have prescribed drugs for my heart condition [Rivaroxaban and bisoprolol] ,can I take Macushield with these drugs , for my AMD condition?

Macushield contains no constituents that will interact in any way with drugs prescribed for your heart condition, and accordingly would recommend that you take Macushield, one tablet once daily.

My dad has macular degeneration and i would like to take macushield. I take methotrexate so can i take both?

Macushield contains no constituents that interact with methotrexate, and so feel free to take the Macushield to optimise your vision and reduce your risk of Macular Degeneration

What is difference between zeaxanthin and meso-zeaxanthin?

In brief they are isomers of each other, however there are important distinctions. First, macular pigment to exert its maximum anti-oxidant effect, it does need Lutein, zeaxanthin and meso-zeaxanthin (i.e. in other words you need three parts of the jigsaw puzzle); Second, meso-zeaxanthin has a slightly different absorbance spectrum for blue light, and this is important for optimal filtration of blue light at the retina; Finally, meso-zeaxanthin is the dominant carotenoid at the very centre of the macula (where zeaxanthin is the dominant carotenoid just off-centre), and therefore if you were to maximise your macular pigment across its spacial profile you would need to take a supplement that contains lutein (which is the dominant carotenoid in the periphery of the macula), zeaxanthin and meso-zeaxanthin.

I am now taking a product called saffron 2020 made by persivita in the uk which contains saffron, lutein,zinc and vitamins. Are you familiar with this product? It does not contain meta-zeaxanthin. I have AMD and am age 70.

In brief, most evidence does suggest that taking a product that contains lutein, zeaxanthin and meso-zeaxanthin is best for maximising your macular pigment across its spacial profile (because meso-zeaxanthin is the dominant carotenoid at the very centre of the macula), and for optimising visual performance (whether or not you have macula disease). Accordingly, and in keeping with the evidence, I would recommend that you take a supplement such as Macushield or Macuhealth (which contain all three macular carotenoids).

I have three (3) questions pertaing to wet macular: Is PreserVision Areds 2 banned in Europe and South America?What is so dangerous? Lutein and Zeaxanthin is more better? MacuHealth containing Meso-Zeaxanthin 10mg, Lutein 10mg, Zeaxanthin 2mg.

The controversy around the preservision AREDS2 formulation centres around its zinc concentration (which may in fact be bad for certain sub types of age related macular degeneration). Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin, and very recent evidence also suggests that only a formulation containing all three macular carotenoids results in optimal vision performance (whether or not you have macular disease).

Is there any evidence base of a beneficial effect of Meso-Zeaxantin as a prophylaxis against Macular Degeneration?

In brief, there is no evidence whatsoever that any of the macular carotenoids are useful for prophylaxis against Macular Degeneration (because such a study would involve thousands of healthy subjects being followed for many decades, and then seeing who developed age macular degeneration and who did not). However, there is evidence that lutein and zeaxanthin do protect against progression of age related macular degeneration and visual loss in subjects with age related macular degeneration, and head-to-head studies have shown that a supplement containing all three of macular pigment constituent carotenoids (and not simply lutein and zeaxanthin as in the AREDS2 study) is superior in terms of augmentation of macular pigment across its spacial profile and in terms of optimisation of vision (whether or not you have macular disease).

I want to take supplements to help prevent getting AMD.but I am confused whether to take a supplement with Zeaxanthin and Meso-Zeaxanthin and Lutein or is just Zeaxanthin and lutein sufficient?

In brief, there three carotenoids that make up macular pigment, these include lutein, zeaxanthin and meso-zeaxanthin. Head-to-head studies have shown that a supplement containing all three macular carotenoids (such as Macushield in Europe or Macuhealth in the USA) is best at augmenting macular pigment across its spacial profile and in optimising vision (whether or not you have macular disease).

Can meso-zeaxanthin be purchased as a separate supplement?

In brief, meso-zeaxanthin cannot be purchased as a separate supplement, but only as a component of a formulation which also contains lutein and zeaxanthin. In brief, it has been shown that you do need all three macular carotenoids for maximum anti-oxidant effect in the central retina.

Using mascara is worst on my eyes if having blepharitis? What could I do?

In brief, if you suffer from blepharitis it is probably a good idea to discontinue the use of mascara for a period of time, treat the blepharitis with any commercially available preservative free artificial tear (these are over-the-counter) and with a regime of lid hygiene. Your local doctor should be able to advise you accordingly.

I am taking a daily supplement of meso-zeaxanthin 10mg, lutein 10mg, and zeaxanthin 2mg. I am 75 years old. Are these the correct dosage for effectiveness? What is the desired dosage for these?

I can assure you that the dosage (in mg) of meso-zeaxantin:lutein:zeaxanthin of 10:10:2 is correct. This is the formulation that is best for augmenting (increasing) across its spacial profile and for optimising vision in patients with age related macular degeneration (and indeed in patients that do not have age related macular degeneration).

I am experiencing blind spots in both eyes and have been told after testing that it is showing very very early stages of Macular Degeneration. Is Macushield the right treatment for this problem?

If you are experiencing blind spots in each eye, these should be assessed by an ophthalmologist. But I can confirm that Macushield is the correct treatment if you have age related macular degeneration, as it contains the best formulation for increasing macular pigment across its spacial profile and for optimising vision in patients with this condition (and indeed in people who do not have any eye disease).

I am having trouble swallowing the capsules that get stuck in my throat. Can you help as tried cutting in half but not possible due to liquid coming out.. Normal tablets I crush or cut as hard ti get down. Can I buy a iquid form of Macushield?

As far as we are aware there is no liquid form of Macushield. The reason for this is that the nutrients within Macushield are not water soluble and need to be protected from light and air. In the absence of taking the supplement directly, other methods that have been shown to increase macular pigment include egg consumption, along with a diet consisting fruit and vegetables.

I am being treated for HBP (Verapamil and Cilazipril) plus the occasional sleeping aid: are there any contra-ndications intaking MacuShield?

Based on studies conducted to date there are no contra indicators with taking other medications. I suggest you consult with a medical doctor regarding this query.

Hi - when i used to close my eyes i would see a very bright gold colour in the shape of a donut with a black centre - now after 4 years of working on a computer this gold colour is very dotty and patchy,is this macular degeneration? And is this a normal colour to see?

It is impossible to do a diagnosis without a proper medical eye examination. It is good practice to have routine visits with an eye doctor who can advise.

Based on research conducted to date, there is no evidence of contra indicators for patients consuming Macushield who are on other medications. However, please consult your medical doctor with this query.

I have Chronic Kidney Disease and am on dialysis. I also have high blood pressure and diabetes. I have recently been recommended Macushield for macualar degeneration. Is it safe for me to take?

Do you have information on Lumega-Z? Guardion Health Sciences , San Diego, CA I can only find information the site puts out?

No, and we are not in a position to comment on products without declared meso-zeaxanthin, but would like to emphasize that the current body of evidence is in favor of a supplement containing all three macular carotenoids (lutein, zeaxanthin and mes-zeaxanthin), such as MacuHealth or Macushield.

I have dry macular degeneration and am taking 1x I Caps daily, as prescribed by the consultant. Can I take the Macushield supplement as well? It does say in the I Caps instructions not to exceed the prescribed dose. I read an article in the Daily Telegraph where a patient said her dry condition had all but disappeared after a course of twelve months. Your advice would be much appreciated.

Certainly, the recommended dose of Macushield for the dry form of age-related macular degeneration is one tablet/day; however, many patients choose to take two/day, and to do so is safe because there is no toxicity associated with the contents of Macushield; Macushield Gold, however, should only be taken once/day.

I have very early AMD and am going to start taking Macushield having just found out about it. What I would like to know is what other vitamins should I be taking and in what quantity? I take Multivitamins for over 70's plus joint capsules which include cod liver oil capsules. Is it possible to take too much? Thats my worry so would appreciate any advise you could give me.

In brief, if you have early AMD, Macushield will be sufficient if you are taking multi-vitamins for over 70s. You cannot take too much Macushield (one tablet a day will be sufficient), as there is no toxicity associated with any of its contents.

Is there any advantage in taking Macushield Gold (vitamins + zinc+copper )or would it be preferable to take Macushield and a good multivitamin?

The only difference between Macushield and Macushield Gold rests on the inclusion of vitamin C, E, Zinc and Copper in Macushield Gold (and these are not in Macushield). Macushield in someone with a healthy diet, or in someone taking a standard multi-vitamin supplement, will suffice in someone with age-related macular degeneration and it is not essential that they take the Macushield Gold (unless he/she has a poor diet). However, it is important that a person does take Macushield (or Macushield Gold) if they have age-related macular degeneration, as the concentrations of its constituent compounds are required in doses which are not found in a typical diet (and therefore supplementation with Macushield or Macushield Gold is required).

I read that some people don't have the enzyme that converts lutein to meso-zeaxanthin. What is the name of the enzyme and is there a test to determine if that enzyme is diminished or not present?

The enzyme that converts lutein to meso-zeaxanthin has not yet been discovered. Indeed, recent evidence is suggesting that, although some retinal meso-zeaxanthin is derived from retinal lutein, dietary sources of meso-zeaxanthin are important (and meso-zeaxanthin is found in edible fish).

1. Verification of Meso-Zeaxanthin in Fish. Nolan JM, Beatty S, Meagher KA, Howard AN, Kelly D, Thurnham DI. J Food Process Technology 5:335. doi: 10.4172/2157-7110.1000335

2. What is meso-zeaxanthin, and where does it come from? Nolan JM, Meagher K, Kashani S, Beatty S. Eye (Lond). 2013 Aug;27(8):899-905
Furthermore, it is not certain that is an enzymatic reaction, and therefore those supplementing are probably best to supplement with a formulation that contains all three macular carotenoids (lutein, zeaxanthin and meso-zeaxanthin).

I am highly allergic to seafood. Does MacuHealth have any form of seafood diritive added. If so, it could be life-threatening for me to take it

A seafood allergy does not represent risk If you take MacuHealth.

Do you have information on Lumega-Z? Guardion Health Sciences , San Diego, CA I can only find inormation the site puts out.

In brief, Lumega-Z from its name appears to contain Omega3 fatty acids. The recent AREDS2 report (published in 2013) shows that inclusion of Omega3 fatty acids in a supplement for age-related macular degeneration are not beneficial. Accordingly, for patients with age-related macular degeneration we recommend a formulation that contains MZ:L:Z (mg) in a ratio of 10:10:2.

I am being treated with Lucentis injections for myopic cnv . Should I stop taking Macushield Gold capsules?

Yes you should continue taking Macushield Gold capsules, as they will reduce your risk of getting problems in the other eye, and also reduce your risk of recurrence (once this course of injections is over) in the eye that is affected by myopic CNV;

I have myopic cnv (right eye), macular pucker (left eye). I have been taking macushield gold since diagnosis but worry I may be over supplementing. Should I revert to macushield plus an omega 3 supplement? I'm in my 40s, healthy diet. My Consultant has said supplements won't help with my condition but I'd prefer to continue.

In brief, you should continue to take Macushield (or Macushield Gold), and should avoid Omega3 supplements (which could actually aggravate your condition; Omega3 supplements were found not to be of benefit in AREDS2); It has recently been shown that taking Macushield (or Macushield Gold) improves vision even in normal people (who don’t have disease), and therefore you should feel no reluctance in continuing with this safe and useful supplement; the paper in question has just been submitted for publication;

I read that taking beta-carotene with Lutein/zeaxanthin/meso-zeaxanthin is not recommended as it competes with these carotenoids. Is it true for Vitamin A palmitate as well? Is it okay to take palmitate 15000 IU daily for someone taking above carotenoids? (eg: Retinitis pigmentosa patient)

In brief, it is probably true that beta-carotene does compete with the macular carotenoids, and is therefore not recommended (also, beta-carotene can increase the risk of lung cancer in smokers); However, this is not true for Vitamin A palmitate, and you can continue to take Vitamin A palmitate as well as the carotenoids;

Are issues with contrast sensitivity or some dimness of vision related to the retina/macula and can zeaxanthin, meso-zeaxanthin, or lutein help? Based on the 2mg, 10mg 10mg formulation of these 3, would taking too much of any one make the issues worse or just not be as effective??

In brief, contrast sensitivity (also known as faintness appreciation) is mediated by the retinal cells at the macula, and is adversely affected by blue light (because of chromatic aberration and also because of blue light scatter); It has recently been shown that the Macushield formulation results in improved contrast sensitivity (at 2 of the 5 spatial frequencies) in subjects who are free of retinal disease, and this paper has just been submitted for publication; In other words, you should continue to take Macushield if you want your vision to be optimised;

Instead of consuming what I would consider to be vast amounts of green vegetables for my early onset AMD would taking Macushield mean that I could eat normal amounts of fruit and veg or should I try to eat more as well as the pills?

Of course, a healthy diet rich in fruit and vegetables is always advisable; however, the implication of your question is correct, in that to achieve the dietary concentrations of lutein, zeaxanthin and meso-zeaxanthin contained in Macushield you would have to eat an inordinate and impossible amount of fruit and vegetables; Furthermore, recent research has shown that consumption of Macushield (or Macushield Gold) results in improved vision in healthy subjects (and in subjects with early age-related macular degeneration) in a way that is simply not replicated in alternative formulations;

Is it safe for someone, female with high ferritin levels (328) to take either Macushield or Macushield Gold?

In brief, the contents of Macushield and the contents of Macushield Gold are not associated with any toxicity or any interactions with ferritin; Accordingly, please feel free to continue taking Macushield or Macushield Gold;

Does meso-zeaxanthin, lutein, or zeaxanthin affect the amount of creatinine in the kidney?

Exhaustive safety studies have been done with the contents of Macushield and Macushield Gold and all studies have shown that there is no abnormality of renal function following consumption of Macushield and Macushield Gold, and that your creatinine level will therefore not be affected by consumption of this naturally occurring and dietary product;

I am Male_24. I have floaters in my both eye and I've started taking MacuGuard. It been 2 weeks and I haven't noticed any difference. Will it work? And how long should I take it?

MacuGuard is not a product covered by this website; I suggest you talk to your eye care professional regarding your symptoms;

At present I am taking Macushield, omega 3 capsules tablets and Astaxanthin tablets. Is it safe to take all three together please. I am having Lucentis injections on a regular basis. Thank you

Yes, it is safe to take Macushield, omega 3 capsules and astaxanthin tablets; however, you should be aware that taking the omega 3 and the astaxanthin does not confer greater protection for your eyes than taking Macushield alone;

I have myopic macular degeneration. Currently, I am taking areds 2 eye vitamin and fish oil. Should I continue taking these plus macushield? Or just take macushield? I am 77 years old. Please tell me the history of macushield.

Macushield contains all three macular carotenoids (lutein, zeaxanthin and meso-zeaxanthin), and confers protection against the progression of age-related macular degeneration and improves vision in people with normal eyes and in people with non-advanced age-related macular degeneration; Myopic macular degeneration is very similar to age-related macular degeneration and, accordingly, it is likely that this supplement will also help with your condition; However, you should bear in mind that taking fish oil (omega 3) does not further protect against progression of myopic macular degeneration than if you were taking Macushield alone;

As I am unable to swallow tablets or capsules would it matter if I chewed the MacuShield capsules?

I think you will find it very difficult to chew the Macushield capsules because of the consistency of their content; the capsules are designed for swallowing whole;

I will be taking Macushleld and wanted to know if it would have an adverse effect to take Cod Liver Oil caps, Bilberry, or Astaxanthin with the Macushield. Since it only contains the three LM and MZ I would need additional vitamins and minerals. Please recommend wether I can take, all or any of the other items too.

Certainly, you can take Macushield in combination with Cod Liver Oil capsules, Bilberry and Astaxanthin. However, taking Macushield alone should be sufficient for your needs, at least in terms of optimising your vision and protecting your macula, as it contains all three macular carotenoids, and I suspect a healthy diet rich in fruit and vegetables will supply you with sufficient levels of the other carotenoids;

I am taking one aspirin per day,is it safe to take macushield?

Yes it is safe to take aspirin with Macushield;

Please advise or send a link to where we can purchase this. The doctor has recommended it for my father.

In Europe this product is known as Macushield, and in North America the exact same product is known as MacuHealth; In the UK, it is available in all Boots Chemists; Furthermore, a link to further ways of purchasing it can be found below:

http://www.macushield.com/products

I have extremely dry eyes would maccushield help, also take betablockers levothyorrine, daily asprin for heart condition

Taking Macushield will not help your dry eyes as it is designed to fortify the nutrient content of your macula (central retina), and has no effect on the surface of the eye;

3 months ago I was diagnosed with Retrobulbar optic neuritis in my right eye,I lost my vision for a while,it's now blurry and foggy especially with movement and when my body heats up. My consultant said it will take a year to calm the optic nerve down and that my sight will not go back to the vision I had before the attack. They said my vision is good in both eyes,just problem with my optic nerve. Would macushield help in any way ?

In short, the answer is no; however, Macushield does help vision in general, and it certainly will not do any harm, and might even enhance your vision (but it will not alter the course of optic neuritis);

Can MacuShield is a lutein (10mg), zeaxanthin (2mg) and meso¬-zeaxanthin (10mg help with my condition of Cystoid macula oedema. I have been on courses of eye drops Maxidex and Acular, and now Nevanac and my doctor tells me that the cysts are not reducing , and my vision is still impaired

There has been no study into the interesting question you have put, but there is a biologically plausible rationale whereby Macushield will assist;

In brief, the constituents of Macushield have antioxidants and anti-inflammatory properties, and given that cCystoid macula oedema, is, in essence, an inflammatory process, there is good reason to expect thatwhy this supplement would be of assistance; Furthermore, Macushield will not do any harm in your case;

My teenage daughter suffers from light sensitivity due to a lack of pigmentation (she is not albino) but has pale blue eyes. would this supplement help ?

In brief, and in theory, it should help with light sensitivity, as glare disability has shown to improve following supplementation with Macushield; furthermore, glare discomfort (this refers to sensitivity to strong lights) also improves following supplementation with a formulation containing the macular carotenoids (such as Macushield);

I have slight and and have been taking macushield for a couple of years and I am suddenly wondering if I should be taking macushield gold instead.

Why is macushield the only product with meso zeaxanthin ? We can't find any products in Australia with meso zeaxanthin .

MZ is only commercially available in the clinically proven ratio of lutein:meso-zeaxanthin:zeaxanthin (in mg) of 10:10:2 in a supplement called Macushield (or Macushield Gold) in the United Kingdom and the EU (and the same formulations are known as MacuHealth [and MacuHealth Plus] in North America); the reasons for this are related to licensing, intellectual property, etc.

I am currently taking Apixaban, Tamsulosin and Tramadol for various conditions. I am also taking Macushield. Is this likely to cause any problems?

There is no known interaction between Macushield and any of the drugs you mention.

I take Macushield on a daily basis and have been advised by a pharmacist that they are only really effective if taken in conjunction with Omega-3. Is there any truth in this?

It is safe to take Macushield and omega 3 capsules however, you should be aware that taking the omega 3 as well does not confer greater protection for your eyes than taking Macushield alone; Omega-3 fatty acid and meso-zeaxanthin are very different compounds with very different functions. Omega-3 is a fatty acid, a naturally occurring fat found in fish and plant oils. Omega-3 is believed to be important as it may help replace the damaged cells at the back of the eye (photoreceptors). Typically these cells at the back of the eye which are required for vision are destroyed when AMD develops. The idea, therefore, is that Omega-3 may help replace the destroyed cells at the back of the eye. However, research has not yet confirmed that this is the case and further study is needed. Meso-zeaxanthin (MZ), on the other hand, is believed to be important as it has the required properties to protect the cells at the back of the eye before they are damaged. In other words, MZ may prevent the disease and Omega-3 may be important to replenish damaged cells. Long story short: Macushield is of proven benefit, omega-3 is not;

I am 60 and was just diagnosed with macular degeneration early stage and they recommended Areds 2 which I just purchased. Buy my research uncovered this product which contains mesozeaxanthin as well. Can I take both products?

The AREDS2 formulation has a higher zinc concentration than the meso-zeaxanthin product (Macushield or Macushield Gold), and these high zinc concentrations may in fact be bad for certain sub-types of age related macular degeneration. Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin, and head-to-head studies have shown that a supplement containing all three macular carotenoids (such as Macushield [or Macushield Gold] in Europe or Macuhealth [or MacuHealth Plus] in the USA) is best at augmenting macular pigment across its spatial profile and in optimising vision (whether or not you have macular disease). Therefore, you should not take the AREDS2 formula and the meso-zeaxanthin-containing formulation together, and we would recommend a meso-zeaxanthin-containing formulation.

Is it ok or safe to take additional zeaxanthin and lutein with this macuhealth formula? There are other formulas on the market that don't haveMZ in them where patients that have AMD are getting good results(reversal of vision loss).The formulas have L and Z+other phytonutrients. Is MZ that essential?

I have received treatment for wet AMD which having been treated with injections, has now been stable for a year. I have been taking a supplement containing MZ but have recently read that the AREDS 2 advised against introducing additional carotenoids in addition to L &Z as this may be counterproductive. As this appears to be in conflict with the results of your studies, I would appreciate your view on this.

Lutein, zeaxanthin and meso-zeaxanthin are all naturally occurring plant pigments, known as carotenoids. The levels of carotenoids you are currently taking have been developed according to a scientific method to provide optimal absorption and minimal waste. Recent studies at Waterford Institute of Technology, Ireland, have shown that the optimal response to these nutrients can be achieved when consumed in the formulation of 10mg, 2mg and 10mg (lutein, zeaxanthin and meso-zeaxanthin respectively). Accordingly, and in keeping with the evidence, I would recommend that you take a supplement such as Macushield (or Macushield Gold) or Macuhealth (or MacuHealth Plus), each of which contain all three macular carotenoids in the clinically proven ratio. The AREDS2 formulation has high amounts of zinc (which may in fact be bad for certain sub types of age related macular degeneration). Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin, and very recent evidence also suggests that only a formulation containing all three macular carotenoids results in optimal vision performance (whether or not you have macular disease).

I have found a supplement with Lutein 300 mg; Meso-Z 200mg; and Zeaxanthin 50 mg . According to all the other supplements I have seen this is way over the top and sounds like a good thing. What do you recommend?

Lutein, zeaxanthin and meso-zeaxanthin are all naturally occurring plant pigments, known as carotenoids. Recent studies at Waterford Institute of Technology, Ireland, have shown that the optimal response to these nutrients can be achieved when consumed in the formulation of 10mg, 2mg and 10mg (lutein, zeaxanthin and meso-zeaxanthin respectively). The doses mentioned by you are very high indeed, and although there is no known toxicity associated with consumption of L or Z or MZ, it would seem wise to stick to the clinically proven formulation (i.e. Macushield or Macushield Gold or MacuHealth or MacuHealth Plus).

My 89 year old Aunt has just been diagnosed with AMD. SHE HAS STARTED TO HAVE INJECTIONS SO PRESUME IT IS WET EYE AMD. CAN MACUSHIELD HELP WET EYE AMD OR ONLY EFFECTIVE FOR DRY EYE?

Macushield contains all three macular carotenoids (lutein, zeaxanthin and meso-zeaxanthin), and confers protection against progression of age-related macular degeneration and improves vision in people with normal eyes and in people with non-advanced age-related macular degeneration (dry AMD). Macushield will not reverse the effects of wet AMD, or alter the course of disease; however, there has been clinical studies conducted at the Nutrition Research Centre Ireland in Waterford has shown that consumption of Macushield (or Macushield Gold) results in improved vision in subjects with early age-related macular degeneration in a way that is simply not replicated in alternative formulations and, accordingly, when the wet AMD ‘settles’ with injection, consumption of Macushield or Macushield Gold will help vision and will reduce risk of recurrence, and so it is advisable to start supplementing now.

I take medication for high blood pressure, statins, and Symbicort and Bricanyl for asthma. Is it okay to take Macushield?

Based on research conducted to date, there is no evidence of contraindications for patients consuming Macushield who are on other medications. However, please consult your medical doctor with this query.

Is there any correlation between the use of 2 MacuHealth capsules a day - am& pm with any stomach/digestive sensitivity especially diarrhea?

Certainly, the recommended dose of Macushield is one tablet/day; however, many patients choose to take two/day, and to do so is safe because there is no toxicity associated with the contents of Macushield; Macushield Gold, however, should only be taken once/day. Based on research conducted to date, there is no evidence of contraindications for patients consuming Macushield who have stomach/digestive sensitivity. However, please consult your medical doctor with this query.

I am 39 years old and have just been told I have 3 or 4 drusen in my right eye. Would macusheild be useful for me to take? I don't have any sight issues yet, I'm also pregnant.

Lutein, zeaxanthin and meso-zeaxanthin are all naturally occurring plant pigments, known as carotenoids. The levels of carotenoids contained in Macusheild have been developed according to a scientific method to provide optimal absorption and minimal waste. Recent studies at Waterford Institute of Technology, Ireland, have shown that the optimal response to these nutrients can be achieved when consumed in the formulation of 10mg, 2mg and 10mg (lutein, zeaxanthin and meso-zeaxanthin respectively). Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin, and very recent evidence also suggests that only a formulation containing all three macular carotenoids results in optimal vision performance (whether or not you have macular disease). However, and given your youth (and therefore low risk of progression), and given that all studies have used pregnancy as an exclusion criterion for recruitment, and in spite of the fact that there is no toxicity associated with consumption of lutein or zeaxanthin or meso-zeaxanthin, it is probably best that you start taking Macushield after your baby is born.,

I have been taking Macushield Gold for Macular Degeneration, however Healthspan produce OptiVision tablets/capsules which contain 20mg Lutein, 2000up Zeaxanthin, I asked Healthspan whether their product contains Meso-Zeaxanthin and they advise me that the body converts the other two ingredients to Meso-Zeaxanthin. Is this correct please.

Lutein, zeaxanthin and meso-zeaxanthin are all naturally occurring plant pigments, known as carotenoids. The levels of carotenoids contained in Macushield have been developed according to a scientific method to provide optimal absorption and minimal waste. Recent studies at Waterford Institute of Technology, Ireland, have shown that the optimal response to these nutrients can be achieved when consumed in the formulation of 10mg, 2mg and 10mg (lutein, zeaxanthin and meso-zeaxanthin respectively). Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin, and very recent evidence also suggests that only a formulation containing all three macular carotenoids results in optimal vision performance (whether or not you have macular disease); Accordingly, we would recommend that you continue to take Macushield Gold.

I would like to have more information on meso-zeazantin

Lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ) are carotenoids (naturally occurring plant pigments). These carotenoids are found at the back of the eye, in the central area of the retina ( the macula). Research has shown that macular pigment (the yellow pigment at the macula believed to protect against age-related macular degeneration [or AMD], and comprising L, Z and MZ) increases upon supplementation with lutein, zeaxanthin and meso-zeaxanthin, and that macular pigment increases are higher when all three are taken together. It used to the thought that L converted to MZ in the retina, but this has now been called into question (see Nolan JM et al, 2013); Lutein, zeaxanthin and meso-zeaxanthin are all naturally occurring plant pigments. The levels of carotenoids contained in Macushield have been developed according to a scientific method to provide optimal absorption and minimal waste. Recent studies at Waterford Institute of Technology, Ireland, have shown that the optimal response to these nutrients can be achieved when consumed in the formulation of 10mg, 2mg and 10mg (lutein, zeaxanthin and meso-zeaxanthin, respectively). Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin, and very recent evidence also suggests that only a formulation containing all three macular carotenoids results in optimal vision performance (whether or not you have macular disease).

I have been taking Areds 2 for a couple of years and my macular degeneration has gone from dry to wet in one eye. Do you think that I should waste my money buying this supplement?

The AREDS2 formulation has a higher zinc concentration than the meso-zeaxanthin product (Macushield or Macushield Gold), and these high zinc concentrations may in fact be bad for certain sub-types of age related macular degeneration. Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin, and head-to-head studies have shown that a supplement containing all three macular carotenoids (such as Macushield [or Macushield Gold] in Europe or Macuhealth [or MacuHealth Plus] in the USA) is best at augmenting macular pigment across its spatial profile and in optimising vision (whether or not you have macular disease). Therefore, we recommend that you replace the AREDS2 formula with a meso-zeaxanthin-containing formulation. Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard,

I am 54 and have had Drusen and/ or Macular Degeneration for many years ( first detected when I was approx 25 years old) . I have been recommended to take Macushield Gold by my optician - it is very expensive. Will it stop the MD from progressing if I take it for the rest of my life now?

Lutein, zeaxanthin and meso-zeaxanthin are all naturally occurring plant pigments, known as carotenoids, and are contained in Macushield/Macushield Gold. Most evidence now suggests that if you want to maximise your macular pigment (and therefore maximise your protection against progression of age related macular degeneration) you need a supplement that contains lutein, zeaxanthin and meso-zeaxanthin. Recent studies at Waterford Institute of Technology, Ireland, have shown that the optimal response to these nutrients can be achieved when consumed in a formulation of 10mg, 2mg and 10mg (lutein, zeaxanthin and meso-zeaxanthin respectively [i.e. Macushield];). Supplementing with MacuShield does not eliminate risk of disease progression, but it does reduce that risk. Accordingly, we would recommend that you continue to take Macushield Gold; Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard,

I wantd to ask you about Macushield side effects on the Liver, would you be kind enough to let me know if there is any you know about ,many thanks.

Based on the considerable body of research conducted to date, there is no evidence of an adverse impact on hepatic (liver) function in association with consumption of Macushield. Of note, all of Macushield’s constituents are found in a healthy diet. Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard,

I was recently diagnosed with AMD and the hospital in Span said I should take AREDSan on daily basis. However, I have read that Macushield which contains Marigold is a better option. I am at a loss as what to take which will help me the best.. I have one dry and one wet eye.

Lutein, zeaxanthin and meso-zeaxanthin are all naturally occurring plant pigments, known as carotenoids, and are contained in Macushield. In contrast, the AREDS2 formulation does not contain meso-zeaxanthin. Recent have shown that the optimal response to these nutrients can be achieved when consumed in the formulation of 10mg, 2mg and 10mg (lutein, zeaxanthin and meso-zeaxanthin respectively [i.e. Macushield]). Accordingly, and in keeping with the evidence, we recommend that you take Macushield (or Macushield Gold) or Macuhealth (or MacuHealth Plus), each of which contain all three macular carotenoids in the clinically proven ratio. Also, the AREDS2 formulation has high amounts of zinc (which may in fact be bad for certain sub-types of age related macular degeneration). Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard,

I notice my eyes get blurry when I use my iPhone for an extended time, would macushield help? Can I take macushield with saffron 2020 pro?

It has recently been shown that Macushield does improve your eye’s sensitivity to contrast (i.e. improves your vision), and so it might help when you use your i-phone for extended periods. However, it may be the case that you need a pair of reading glasses, and we would recommend you get tested in this regard by your local optometrist. Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard,

It says on the packet of macusheild gold to take 3 capsules a day which I have been doing for two weeks but I have developed a head ache and back ache. am I taking the right amount or would it be ok to lower the dose?

You should take one Macushield softgel, and two Gold softgel capsules, per day, with a meal. Based on a substantial body of published research, there is no evidence of clinically important adverse reactions in association with consumption of Macushield Gold when taken in accordance with instructions. Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard,

I started taking one tablet of MacuHealth daily 80 days ago. In the same time period I've gained 10 pounds. Could there be any correlation between these?

Based on the substantial body of published research, there have been no reports of weight gain in association with consumption of MacuHealth. Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard,

I have hereditary Retintis Pigmentosa . Would this supplement help? Or does it only help people with AMD.

In short, the answer is ‘no’; however, Macushield does help vision in general, and it certainly will not do any harm, and might even enhance your vision (but it will not alter the course of retinitis pigmentosa); Of course, this advice should be tailored to your particular medical circumstances, and so we therefore also recommend that your supervising physician plays a role in the decision-making process in this regard.